The Sioux City Lewis & Clark Interpretive Center showcases permanent exhibits about the Corps of Discovery's time in the present-day Sioux City area, from late July to early September 1804. The death and burial of Sergeant Charles Floyd on Aug. 20, 1804, is at the center of the story. Floyd was the first U.S. soldier to die west of the Mississippi River.

The expedition as a military operation comes to life in exhibits that use interactive devices, including animatronic mannequins, computers, flip books, stamping stations, text-and-graphic panels, lift-and-drop panels, handpainted murals, a brass-rubbing station, and reproductions of military equipment.

The Traditional Native Games exhibit displays more than two dozen reproductions of games artifacts housed at the Buechel Lakota Memorial Museum at St. Francis Mission on the Rosebud Reservation in South Dakota. The Center's Buffalo Robe exhibit highlights the role of the buffalo to Native peoples.

The Floyd Memorial Association exhibit illuminates the community effort that resulted in the Floyd Monument, the first National Historic Landmark designated by the National Park Service and the U.S. Department of the Interior. The Center's exhibit includes a replica of the obelisk.

The Keelboat Theatre recalls the 55-foot-long vessel of the Lewis & Clark Expedition. DVD presentations on exploration and Native cultures topics are shown daily. The Center's Spirit of Discovery Store offers a range of books and gift items for all ages.

The grounds feature a 30-by-50-foot U.S. Flag atop a 150-foot flag pole. The 14-foot-tall bronze "Spirit of Discovery" sculpture depicts Lewis, Clark and Lewis's Newfoundland dog, Seaman.